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  • What medicine should i take for toothache
  • Extreme tooth pain can't sleep.

    What Is the Best Toothache Medicine?

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  • Some of the best toothache medicines are not necessarily found on drugstore shelves. Although over-the-counter (OTC) painkillers and topical anesthetics can be very effective at easing toothache pain, there are things around the house that may be just as effective, including ice application and saltwater rinses.

    Head elevation can also help ease toothache pain at night.

    Over-the-Counter Pain Medicines

    One of the first things people typically do when faced with a toothache is reach for OTC oral painkillers.

    Hole in tooth pain relief

    There are two main types that help ease pain in slightly different ways.

    NSAIDs

    The American Dental Association (ADA) recommends nonsteroidal anti-inflammatory drugs (NSAIDs) as the first-line treatment option for uncomplicated tooth pain.

    NSAIDs work by blocking the enzyme cyclooxygenase (COX) that triggers the release of inflammatory compounds known as prostaglandins, which are involved in pain signaling.

    By doing so, NSAIDs can reduce inflammation along with pain.

    OTC NSAIDs commonly used for this include:

    NSAIDs shou

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